Jiménez, José LuisGómez, RafaelBriz, VeronicaMadrid González, RicardoBryszewsk, MariaMata, Francisco .Javier. de laMuñoz-Fernández, María Ángeles2024-02-062024-02-062012Jiménez, J. L., et al. «Carbosilane Dendrimers as Carriers of siRNA». Journal of Drug Delivery Science and Technology, vol. 22, n.o 1, 2012, pp. 75-82. https://doi.org/10.1016/S1773-2247(12)50007-9.1773-224710.1016/s1773-2247(12)50007-9https://hdl.handle.net/20.500.14352/99626Acknowledgements Sources of financial support: Grants from MNT-ERA NET transnational call 2007; COST Action (TD0802), Red RIS RD06-0006-0035, Fondo de Investigación Sanitaria (PI09/02029; PI080222; PI081495), Fundación para la Investigación y la Prevención del SIDA en España (FIPSE 240800/09), EuroEraNet DENPEPTHIV PS09/02669, DENANORNA, and CIBER-BBN del Instituto de Salud Carlos III. JLJF is supported by Programa de Investigación de la Consejería de Sanidad de la Comunidad de Madrid.Despite the enormous possibilities of RNAi, there still exist many problems that need to be addressed. Obstacles in delivery, target cell transfection, stability/degradation, transient activity, secondary effects, toxicity caused by the delivery vector, and resistance all hinder the path of carrying out in vivo experiments with RNAi and further developing RNAi as a new therapy for clinical use. Notwithstanding, the majority of research that uses RNAi depends on a delivery vector of some kind. This review offers a brief overview of the current status of carbosilane dendrimers as siRNA delivery vectors.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article2588-8943https://doi.org/10.1016/S1773-2247(12)50007-9restricted access575RNAiCarbosilane dendrimersDendrimersNon-viral vectorsHIV infectionGenética2409 Genética