The preventive and therapeutic consumption of meat enriched with carob fruit extract, rich in phenolic compounds, improves colonic antioxidant status in late-stage T2DM rats

Macho González, AdriánApaza Ticona, Luis NestorRedondo Castillejo, RocíoHernández Martín, MarinaSánchez Muniz, Francisco JoséHernáiz, María JoséBastida Codina, SaraBenedí González, Juana MaríaBocanegra De Juana, AranzazuLópez-Oliva Muñoz, María ElviraMateos Vega, CarmenGarcimartín Álvarez, Alba2024-11-192024-11-192024-08-30Macho-González A, Apaza Ticona L, Redondo-Castillejo R, Hernández-Martín M, Sánchez-Muniz FJ, Hernáiz MJ, Bastida S, Benedí J, Bocanegra A, López-Oliva ME, Mateos-Vega C, Garcimartín A. The preventive and therapeutic consumption of meat enriched with carob fruit extract, rich in phenolic compounds, improves colonic antioxidant status in late-stage T2DM rats. Food Chem. 2024 Aug 30;450:139339. doi: 10.1016/j.foodchem.2024.1393390308-814610.1016/j.foodchem.2024.139339https://hdl.handle.net/20.500.14352/110793Oxidative stress is prevalent in Type 2 Diabetes Mellitus (T2DM) and has been associated with high meat consumption. Carob Fruit Extract (CFE) contains phenolic compounds, making it a suitable functional ingredient. Current study aims to evaluate the effect of CFE-enriched meat (CFE-meat) consumption on the antioxidant status of proximal and distal colon, and its relationship with fecal phenolic compounds in late-stage T2DM rats. Three groups of eight rats were studied: 1) D, fed control-meat; 2) ED, fed CFE-meat since the beginning of the study; 3) DE, fed CFE-meat after confirming T2DM. CFE-meat consumption reduces colonic oxidative stress mainly in the proximal section and helps to ameliorate glutathione metabolism and antioxidant score. Difference between ED and DE groups were associated with colon homeostasis and T2DM progression suggesting greater fermentation but lower absorption in the DE group. CFE appears as a promising tool to improve the antioxidant status observed in late-stage T2DM.engAttribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/The preventive and therapeutic consumption of meat enriched with carob fruit extract, rich in phenolic compounds, improves colonic antioxidant status in late-stage T2DM ratsjournal articlehttps://doi.org/10.1016/j.foodchem.2024.139339open accessNMRFunctional meat2-phenyl chromaneColonic oxidative stressFecal phenolic compoundsProximal and distal colonCiencias Biomédicas32 Ciencias Médicas