Nieto Barbero, María AsunciónSanchez-Pernaute, OlgaVadillo, CristinaRodriguez-Nieto, Maria JesusRomero-Bueno, FredeswindaLópez-Muñiz, BelenCebrian, LauraRio-Ramirez, Maria TeresaLaporta, RosaliaBonilla, GemaCobo, TatianaLeon, LeticiaAbasolo, LydiaNieto, Maria AsuncionVadillo, CristinaLores, Irene Martínde Castro, Ana Bustos GarciaRomero Bueno, FredeswindaRodriguez Nieto, Maria JesusPernaute, Olga SanchezPalacios, CarmeloCarrera, Luis GomezBonilla, GemaOrtega, Gemma MoraCobo, TatianaLópez Muñiz, BelénCebrián, LauraGodoy, HildaLaporta, RosaliaCubas, Irene LlorenteValenzuela, Claudiade Vicuña, Rosario GarciaJauregui, AnaRigual, JuanMartos, Jesús LoarceHita, Jose Luis Morell2026-04-152026-04-152023-01-18Nieto, M.A., Sanchez-Pernaute, O., Vadillo, C. et al. Functional respiratory impairment and related factors in patients with interstitial pneumonia with autoimmune features (IPAF): Multicenter study from NEREA registry. Respir Res 24, 19 (2023). https://doi.org/10.1186/s12931-023-02317-51465-993X10.1186/s12931-023-02317-5https://hdl.handle.net/20.500.14352/134799Background The objective of the present study is to describe the characteristics of interstitial pneumonia with autoimmune features (IPAF) patients, to assess the incidence rate of functional respiratory impairment over time and to evaluate the influence of therapeutic alternatives on the prognosis of these patients. Methods A longitudinal observational multicenter study was performed (NEREA registry). It was carried out by a multidisciplinary team in seven Hospitals of Madrid. Patients were included from IPAF diagnosis. Main outcome: poor prognosis as functional respiratory impairment (relative decline in FVC % defined as≥5% every 6 months). Covariates: therapy, sociodemographic, clinical, radiological patterns, laboratory and functional tests. Statistics: Survival tech‑ niques were used to estimate IR per 100 patients-semester with their 95% confidence interval [CI]. The influence of covariates in prognosis were analyzed through cox multivariate regression models (hazard ratio (HR) and [CI]). Results 79 IPAF were included, with a mean and a maximum follow-up of 3.17 and 12 years respectively. Along the study, 77.2% received treatment (52 glucocorticoids, 25 mycophenolate, 21 azathioprine, 15 rituximab and 11 antifibrotics). IR was 23.9 [19.9–28.8], and 50% of IPAF developed functional respiratory impairment after 16 months from its diagnosis. Multivariate analysis: usual interstitial pneumonia (UIP) had poorer prognosis compared to nonspecific interstitial pneumonia (NSIP) (p=0.001). In NSIP, positive ANA, increased the risk of poor prognosis. In UIP, glucocorticoids (HR: 0.53 [0.34–0.83]), age (HR: 1.04 [1.01–1.07]), and Ro-antibodies (HR: 0.36 [0.19–0.65]) influenced the prognosis. Conclusions IPAF have functional impairment during the first years of disease. Factors predicting deterioration differengAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal articlehttps://doi.org/10.1186/s12931-023-02317-5https://link.springer.com/article/10.1186/s12931-023-02317-5open accessInterstitial pneumonia with autoimmune featuresRisk factorsPrognosisPrognosisNeumología32 Ciencias Médicas