Rodríguez‐Nogales, CarlosDesmaële, DidierSebastián, VíctorCouvreur, PatrickBlanco‐Prieto, María J.2026-02-232026-02-232021Rodríguez‐Nogales C, Desmaële D, Sebastián V, et al. Decoration of Squalenoyl‐Gemcitabine Nanoparticles with Squalenyl‐Hydroxybisphosphonate for the Treatment of Bone Tumors. ChemMedChem 2021;16:3730–8. https://doi.org/10.1002/cmdc.2021004641860-71791860-718710.1002/cmdc.202100464https://hdl.handle.net/20.500.14352/132893Therapeutic perspectives of bone tumors such as osteosarcoma remain restricted due to the inefficacy of current treatments. We propose here the construction of a novel anticancer squalene-based nanomedicine with bone affinity and retention capacity. A squalenyl-hydroxybisphosphonate molecule was synthetized by chemical conjugation of a 1-hydroxyl-1,1-bisphosphonate moiety to the squalene chain. This amphiphilic compound was inserted onto squalenoyl-gemcitabine nanoparticles using the nanoprecipitation method. The co-assembly led to nanoconstructs of 75 nm, with different morphology and colloidal properties. The presence of squalenyl-hydroxybi-sphosphonate enhanced the nanoparticles binding affinity for hydroxyapatite, a mineral present in the bone. Moreover, the in vitro anticancer activity was preserved when tested in commercial and patient-treated derived pediatric osteosarcoma cells. Further in vivo studies will shed light on the potential of these nanomedicines for the treatment of bone sarcomas.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1002/cmdc.202100464open access616-006.04Ciencias BiomédicasOncología32 Ciencias Médicas