Fernández Miranda, ConsueloPulido Ortega, FedericoCarrillo, Juan L.Larumbe, SagrarioGómez Izquierdo, TeresaOrtuño, BlancaRubio García, Rafaeldel Palacio, Ángel2024-08-012024-08-011998-06-08Fernández-Miranda C, Pulido F, Carrillo JL, Larumbe S, Gómez Izquierdo T, Ortuño B, Rubio R, del Palacio A. Lipoprotein alterations in patients with HIV infection: relation with cellular and humoral immune markers. Clin Chim Acta. 1998 Jun 8;274(1):63-700009-898110.1016/S0009-8981(98)00050-3https://hdl.handle.net/20.500.14352/107332In order to determine lipid abnormalities in serum in HIV-infected patients and their relation with humoral and cellular immunological changes. Ninety HIV-infected patients without acute inflammatory or malignant disease have been studied. Thirty healthy HIV-negative subjects constituted the control group. As compared with controls, patients with CD4 + lymphocytes > 400 x 10(6)/l had higher triglycerides and lower high density lipoprotein (HDL)-cholesterol and apolipoprotein (apo)-A1. Lipoprotein comparison by groups of patients according to CD4 + cell counts showed a decrease of HDL-cholesterol in patients with CD4 + cells < or = 200 x 10(6)/l. When CD4 + lymphocyte counts were < 50 x 10(6)/l, total and very low density lipoprotein (VLDL)-triglycerides and VLDL-cholesterol were increased and HDL and low density lipoprotein (LDL)-cholesterol and apo-A1 were decreased. Interferon (IFN)-alpha, beta2-microglobulin and tumor necrosis factor (TNF)-alpha were correlated positively with total and VLDL-triglycerides and negatively with HDL-cholesterol. In conclusion, lipoprotein changes in patients with HIV-infection are related with humoral and cellular immune markers. A decrease of HDL-cholesterol and apo-A1 and an increase of triglyceride levels could be considered as markers of disease progression.engjournal articlehttps://doi.org/10.1016/S0009-8981(98)00050-39681598https://www.sciencedirect.com/science/article/pii/S0009898198000503restricted access616.98VIHLipoprotein alterationsHIVcellular immune markershumoral immune markersCiencias Biomédicas32 Ciencias Médicas