Molina Moreno, RicardoEspinosa Góngora, CarmenGálvez Esteban, Rosa MaríaMontoya Matute, AnaDescalzo, Miguel ÁngelJiménez Alonso, María IsabelDado, DianaMiró Corrales, Guadalupe2024-11-072024-11-072012Molina R, Espinosa-Góngora C, Gálvez R, Montoya A, Descalzo MA, Jiménez MI, Dado D, Miró G. (2012). Efficacy of 65% permethrin applied to dogs as a spot-on against Phlebotomus perniciosus. Veterinary Parasitology, 187(3-4):529-33.0304-401710.1016/j.vetpar.2012.01.024https://hdl.handle.net/20.500.14352/110230Supplementary data associated with this article can be found, in the online version, at doi:10.1016/j.vetpar.2012.01.024.Leishmania infantum is a protozoan parasite causing leishmaniosis, a visceral disease transmitted by the bites of sand flies. As the main reservoir of the parasite, dogs are the principal targets of control measures against this disease, which affects both humans and dogs. Several studies have revealed the usefulness of topical insecticide treatment (collars, spot-ons and sprays) in reducing the incidence and prevalence of L. infantum. The present study was designed to test the efficacy of 65% permethrin applied to dogs as a spot-on against the sand fly vector Phlebotomus perniciosus. The duration of the desired effects was also estimated to help design an optimal treatment regimen. Twelve dogs assigned to treatment (n = 6) and control (n = 6) groups were exposed to sand flies once a week over a seven-week period. Repellent and insecticidal efficacies were estimated and compared amongst the groups. Our findings indicate satisfactory repellent, or anti-feeding, effects lasting 3 weeks and short-term insecticidal effects lasting 2 weeks after initial application. Accordingly, we recommend the use of this product every 2–3 weeks during the active phlebotomine sand fly period to protect dogs against the bites of P. perniciosus.engjournal article1873-2550https//doi.org/10.1016/j.vetpar.2012.01.024https://www.sciencedirect.com/science/article/pii/S030440171200043X?via%3Dihubopen accessCanine leishmaniosisPhlebotomus perniciosusLeishmania infantumDogPermethrinVeterinariaSanidad animal3109 Ciencias Veterinarias