Guzmán Solis, EduardoSantini, EvaFerrari, MicheleLiggieri, LiberoRavera, Francesca2023-06-222023-06-222022-01-260013-936X10.1021/acs.est.1c06885https://hdl.handle.net/20.500.14352/71546CRUE-CSIC (Acuerdos Transformativos 2022)The interaction of hydrophobic silicon dioxide particles (fumed silicon dioxide), as model air pollutants, and Langmuir monolayers of a porcine lung surfactant extract has been studied in order to try to shed light on the physicochemical bases underlying the potential adverse effects associated with pollutant inhalation. The surface pressure−area isotherms of lung surfactant (LS) films including increasing amounts of particles revealed that particle incorporation into LS monolayers modifies the organization of the molecules at the water/vapor interface, which alters the mechanical resistance of the interfacial films, hindering the ability of LS layers for reducing the surface tension, and reestablishing the interface upon compression. This influences the normal physiological function of LS as is inferred from the analysis of the response of the Langmuir films upon the incorporation of particles against harmonic changes of the interfacial area (successive compression−expansion cycles). These experiments evidenced that particles alter the relaxation mechanisms of LS films, which may be correlated to a modification of the transport of material within the interface and between the interface and the adjacent fluid during the respiratory cycle.engAtribución 3.0 Españajournal articlehttps://doi.org/10.1021/acs.est.1c06885open access544lung surfactantmonolayersrheologysurface pressureparticlesphysiological responsepollutionQuímica física (Química)