Ponz Lueza, VirginiaLópiz Morales, María YaizaRodríguez Bobada, María CruzTornero Esteban, PilarArvinius, CamilaGarcía Fernández, CarlosSeara Lifante, D.Rojo Pérez, Francisco JavierMarco Martínez, Fernando2024-08-192024-08-192024-01-01Ponz-Lueza V, Lopiz Y, Rodríguez-Bobada C, Tornero-Esteban P, Arvinius C, García-Fernández C, Seara-Lifante D, Rojo-Pérez FJ, Marco F. Efficacy of transplantation of lipoaspired mesenchymal stem cells in the treatment of chronic rotator cuff tears. Experimental model in rats. Rev Esp Cir Ortop Traumatol. 2024 Jan-Feb;68(1):9-17. English, Spanish. doi: 10.1016/j.recot.2023.05.006. Epub 2023 May 23. PMID: 37230410.1888-441510.1016/j.recot.2023.05.006https://hdl.handle.net/20.500.14352/107476Background and aim: Rotator cuff tears emerge in approximately 30% of the population over 60 years of age. Arthroscopic surgical treatment of these lesions is the treatment of choice, however, despite the improved repair techniques, the rate of re-tears ranges between 11 and 94%. Therefore, researchers seek to improve the biological healing process through the use of different alternatives such as mesenchymal stem cells (MSCs). Our objective is to evaluate the efficacy of a Cellular Therapy Drug made from allogeneic stem cells derived from adipose tissue in a rat model of chronic rotator cuff injury. Material and methods: The supraspinatus lesion was created in 48 rats for subsequent suturing at 4 weeks. MSCs in suspension were added to 24 animals after suturing, and HypoThermosol-FRS® (HTS) to 24 animals as a control group. Histology (Åström and Rausing scale) and the maximum load, displacement and elastic constant of the supraspinatus tendon were analyzed in both groups 4 months after the repair. Results: No statistically significant differences were found in the histological score comparing the tendons treated with MSCs with respect to the tendons treated with HTS (P=.811) nor in the results of maximum load (P=.770), displacement (P=.852) or elastic constant (P=.669) of the tendon in both groups. Conclusions: The addition of adipose-derived cells in suspension to the repair of a chronic cuff injury does not improve the histology or biomechanics of the sutured tendon.engAttribution-NonCommercial-NoDerivatives 4.0 Internationaljournal article1988-8856https://doi.org/10.1016/j.recot.2023.05.006https://www.sciencedirect.com/science/article/pii/S1888441523001261open access617611.013.9Adipose stem cellsCellular therapyChronic rotator cuff tearCélulas madre adiposasCélulas madre mesenquimalesHypoThermosolMesenchymal stem cellsRatRotura crónica manguito rotadorTerapia celularCiencias Biomédicas32 Ciencias Médicas