Cabrera González, Justo EnriqueIllescas Martínez, Beatriz MaríaMartín León, NazarioGallego, IvánRamos‐Soriano, JavierMéndez‐Ardoy, AlejandroIrene Lostalé‐SeijoJose J. ReinaJavier Montenegro2024-01-122024-01-122022-09-06Angew. Chem. Int. Ed. 2022, 61, e2022100430044-82491521-375710.1002/ange.202210043https://hdl.handle.net/20.500.14352/92739Fully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis‐adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E‐selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials.engjournal article1521-3773open access547FullerenesGlycomimeticLectinMultivalencyPeptidesQuímica orgánica (Química)2306 Química Orgánica23 Química