Wang, XiaojingLu, QirongGuo, JingchaoAres Lombán, IrmaMartínez Caballero, MartaMartínez Larrañaga, María RosaWang, XuAnadón Navarro, Arturo RamónMartínez Caballero, María Aranzazu2024-01-312024-01-312022Wang X, Lu Q, Guo J, Ares I, Martínez M, Martínez-Larrañaga MR, Wang X, Anadón A, Martínez MA. Oxidative Stress and Metabolism: A Mechanistic Insight for Glyphosate Toxicology. Annu Rev Pharmacol Toxicol. 2022 Jan 6;62:617-639. doi: 10.1146/annurev-pharmtox-020821-111552. PMID: 34990202.1545-430410.1146/annurev-pharmtox-020821-111552https://hdl.handle.net/20.500.14352/97293Glyphosate (GLYP) is a widely used pesticide; it is considered to be a safe herbicide for animals and humans because it targets 5-enolpyruvylshikimate-3-phosphate synthase. However, there has been increasing evidence that GLYP causes varying degrees of toxicity. Moreover, oxidative stress and metabolism are highly correlated with toxicity. This review provides a comprehensive introduction to the toxicity of GLYP and, for the first time, systematically summarizes the toxicity mechanism of GLYP from the perspective of oxidative stress, including GLYP-mediated oxidative damage, changes in antioxidant status, altered signaling pathways, and the regulation of oxidative stress by exogenous substances. In addition, the metabolism of GLYP is discussed, including metabolites,metabolic pathways, metabolic enzymes, and the toxicity of metabolites. This review provides new ideas for the toxicity mechanism of GLYP and proposes effective strategies for reducing its toxicity.engjournal articlehttps://doi.org/10.1146/annurev-pharmtox-020821-11155234990202restricted access61GlyphosateGLYPToxicityMetabolismAntioxidantsCiencias Biomédicas3214 Toxicología