Prieto Montero, RuthPrieto Castañeda, AlejandroKatsumiti, AlbertoSola Llano, RebecaRodríguez Agarrabeitia, AntoniaCajaraville, Miren P.Ortiz García, María JosefaMartínez Martínez, Virginia2023-06-162023-06-162021-12-04Prieto Montero, R., Prieto Castañeda, A., Katsumiti, A. et al. «Red haloBODIPYs as Theragnostic Agents: The Role of the Substitution at Meso Position». Dyes and Pigments, vol. 198, febrero de 2022, p. 110015. DOI.org (Crossref), https://doi.org/10.1016/j.dyepig.2021.110015.0143-720810.1016/j.dyepig.2021.110015https://hdl.handle.net/20.500.14352/4603Three different molecular designs based on BODIPY dye have been proposed as photosensitizers (PSs) for photodynamic therapy (PDT) by the inclusion of halogen atoms (Iodine) at 2,6-positions and with extended conjugation at 3, 5-positions and varying the substitution at meso position. The synthesis is described and their main photophysical features including singlet oxygen production and triplet states were characterized by absorption and fluorescence spectroscopy (steady-state and time-correlated) and nanosecond transient absorption spectroscopy. The results were compared with the commercial Chlorin e6. The three new red-halogen-BODIPYs showed a great balance between singlet oxygen generation (ΦΔ≥0.40) and fluorescence (Φfl≥0.22) for potential application on PDT, and particularly in theragnosis. In vitro experiments in HeLa cells were done to study their performance and to elucidate the best potential candidate for PDT.engAtribución-NoComercial-SinDerivadas 3.0 Españajournal articlehttps://doi.org/10.1016/j.dyepig.2021.110015open access547.1:615.8543.426615.8BODIPY photosensitizerSinglet oxygenPhotodynamic therapyHeLa cellsTheragnosisQuímica física (Física)Química orgánica (Química)2210 Química Física2306 Química Orgánica