Barber, DomingoFernández Arias, CristinaCarrera, Ana2024-01-292024-01-292005Barber, D., Bartolomé, A., Hernandez, C. et al. PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus. Nat Med 11, 933–935 (2005). https://doi.org/10.1038/nm12911546-170X10.1038/nm1291https://hdl.handle.net/20.500.14352/96062Systemic lupus erythematosus (SLE) is a chronic inflammatory disease generated by deregulation of T cell–mediated B-cell activation, which results in glomerulonephritis and renal failure. Disease is treated with immunosuppressants and cytostatic agents that have numerous side effects. Here we examine the use of inhibitors of phosphoinositide 3-kinase (PI3K) γ, a lipid kinase that regulates inflammation, in the MRL-lpr mouse model of SLE. Treatment reduced glomerulonephritis and prolonged lifespan, suggesting that P13Kγ may be a useful target in the treatment of chronic inflammation.engjournal articlehttps://doi.org/10.1038/nm1291https://pubmed.ncbi.nlm.nih.gov/16127435/restricted access612.017Ciencias Biomédicas24 Ciencias de la Vida2412 Inmunología