Nevzorova, YuliaLiedtke, Christian2024-02-022024-02-022011-12-21Nevzorova YA, Liedtke C. Sh(i)pping signals protect against Stat3-driven liver cancer. Hepatology. 2012 Jan;55(1):322-4. doi: 10.1002/hep.2474210.1002/hep.24742https://hdl.handle.net/20.500.14352/98107The human gene PTPN11, which encodes the tyrosine phosphatase Shp2, may act as a proto-oncogene because dominantly activating mutations have been detected in several types of leukemia. Herein we report a tumor-suppressor function of Shp2. Hepatocyte-specific deletion of Shp2 promotes inflammatory signaling through the Stat3 pathway and hepatic inflammation/necrosis, resulting in regenerative hyperplasia and development of tumors in aged mice. Furthermore, Shp2 ablation dramatically enhanced diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) development, which was abolished by concurrent deletion of Shp2 and Stat3 in hepatocytes. Decreased Shp2 expression was detected in a subfraction of human HCC specimens. Thus, in contrast to the leukemogenic effect of dominant-active mutants, Ptpn11/Shp2 has a tumor-suppressor function in liver.engjournal articlehttps://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep.24742https://pubmed.ncbi.nlm.nih.gov/22190379/restricted access57Ciencias BiomédicasBiologíaGastroenterología y hepatologíaBiología molecular (Biología)24 Ciencias de la Vida2411.07 Fisiología de la Digestión3205.03 Gastroenterología2415 Biología Molecular