Sánchez Salcedo, SandraMalavasi, GianlucaSalinas Sánchez, Antonio J.Lusvardi, GigliolaRigamonti, LucaMenabue, LediVallet Regí, María Dulce Nombre2023-06-172023-06-172018-03-021996-194410.3390/ma11030367https://hdl.handle.net/20.500.14352/12709Beneficial effects in bone cell growth and antibacterial action are currently attributed to Ga3+ ions. Thus, they can be used to upgrade mesoporous bioactive glasses (MBGs), investigated for tissue engineering, whenever they released therapeutic amounts of gallium ions to the surrounding medium. Three gallium-enriched MBGs with composition (in mol %) xSiO2–yCaO–zP2O5–5Ga2O3, being x = 70, y = 15, z = 10 for Ga_1; x = 80, y = 12, z = 3 for Ga_2; and x = 80, y = 15, z = 0 for Ga_3, were investigated and compared with the gallium-free 80SiO2–15CaO–5P2O5 MBG (B). 29Si and 31P MAS NMR analyses indicated that Ga3+ acts as network modifier in the glass regions with higher polymerization degree and as network former in the zones with high concentration of classical modifiers (Ca2+ ions). Ga_1 and Ga_2 exhibited a quick in vitro bioactive response because they were coated by an apatite-like layer after 1 and 3 days in simulated body fluid. Although we have not conducted biological tests in this paper (cells or bacteria), Ga_1 released high but non-cytotoxic amounts of Ga3+ ions in Todd Hewitt Broth culture medium that were 140 times higher than the IC90 of Pseudomonas aeruginosa bacteria, demonstrating its potential for tissue engineering applications.engAtribución 3.0 Españajournal articlehttps://doi.org/10.3390/ma11030367https://www.mdpi.com/1996-1944/11/3/367open access615.4gallium ionsmesoporous glassesglass structurein vitro bioactivityantibacterial capabilityQuímica farmaceútica2390 Química Farmacéutica