Wang, XiaohuiLi, HoupengWang, SimengMartínez Caballero, María AranzazuMartínez Caballero, MartaAres Lombán, IrmaMartínez Larrañaga, María RosaWang, XuAnadón Navarro, Arturo RamónMaximiliano Guerra, Jorge Enrique2025-10-132025-10-132023Wang, X., Li, H., Wang, S., Martínez, M.-A., Ares, I., Martínez, M., Martínez-Larrañaga, M.-R., Wang, X., Anadón, A., & Maximiliano, J.-E. (2022). [Rev. of Tefluthrin: metabolism, food residues, toxicity, and mechanisms of action]. Critical Reviews in Toxicology, 52(8), 664-680. https://doi.org/10.1080/10408444.2022.21433201040-8444https://doi.org/10.1080/10408444.2022.2143320https://hdl.handle.net/20.500.14352/124851Tefluthrin is a Type I pyrethroid insecticide widely used all over the world. Residues of tefluthrin in various agricultural and animal-derived products may be related to potential human health risks. Tefluthrin metabolism in mammals involves hydrolysis of the ester bond to form cyclopropane acid and 4-methylbenzyl alcohol moieties, followed by oxidation. In this review manuscript, we provide crucial information regarding the toxicity of pyrethroids and propose natural antioxidants for amelioration poisoning in humans and animals. We call for the rational use of tefluthrin as an agrochemical product and for greater attention to the residual toxicity caused by tefluthrin in primary and succeeding crops. This greater attention is required given the global use of tefluthrin.engjournal article1547-6898https://doi.org/10.1080/10408444.2022.214332036625435restricted access615.9TefluthrinFood residuesMechanismOxidative stressToxicityCiencias Biomédicas3214 Toxicología