Suárez Blas, FátimaMartínez Fernández, MarcosPrieto Castañeda, AlejandroGarcía Fernández, AlbaMartínez Ruíz, José I.Ramos Gallego, María MarOrtiz García, María JosefaMartínez Máñez, RamónSegura Castedo, José Luis2024-07-112024-07-112023-11Fátima Suárez-Blas, Marcos Martínez-Fernández, Alejandro Prieto-Castañeda, Alba García-Fernández, José I. Martínez, María Mar Ramos, María J. Ortiz, Ramón Martínez-Máñez, José L. Segura, BODIPY doping of covalent organic frameworks-based nanomaterials: A novel strategy towards biomedical applications, Dyes and Pigments, Volume 219, 2023, 111561, ISSN 0143-7208, https://doi.org/10.1016/j.dyepig.2023.111561.0143-720810.1016/j.dyepig.2023.111561https://hdl.handle.net/20.500.14352/105944Covalent organic Frameworks (COFs) are a class of crystalline macromolecular materials build-up by monomers with specific symmetries or functionalities. There are important limitations in the synthesis of highly ordered COFs, such as the shape and packing of the building blocks. Thus, the presence of fluorine atoms that lie perpendicular to the bisecting plane of BODIPY derivatives together with the presence of four bulky methyl groups could hinder the crystallization process in COF synthesis. For that reason, BODIPY-based COFs are rarely incorporated to COF networks. In this work, following the mixed linker strategy, a pre-synthetic method to dope COF structures with BODIPY units was developed. The materials have been processed into fluorescent Covalent Organic Nanosheets (CONs) with defined particle-size distributions around 100 nm, suitable for cellular biomedical applications. The viability of the CONs was evaluated using Sk-Mel-103 cells, demonstrating the internalization showing 100% cell viability. We envisage that this work could accelerate the discovery of new COF-based materials for biomedical sciencesengAttribution-NonCommercial-NoDerivatives 4.0 Internationaljournal articlehttps://doi.org/10.1016/j.dyepig.2023.111561https://www.sciencedirect.com/journal/dyes-and-pigmentsopen access547COFBODIPYInternalizationDopingFrameworksQuímica orgánica (Química)2306 Química Orgánica