Valcárcel Olmeda, ÁngelaBriones Montero, AndreaRodero Martínez, MartaGonzález Fernández, JuanOlmeda García, Ángeles SoniaValcárcel, FélixCuéllar Del Hoyo, María Del Carmen2024-05-242024-05-242024-05-13Valcárcel, Á., Montero, A.B., Rodero, M., González-Fernández, J., Olmeda, A.S., Valcárcel, F. et al. (2024) Alpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum. Medical and Veterinary Entomology, 1–6. Available from: https://doi.org/10.1111/mve.127240269-283X10.1111/mve.12724https://hdl.handle.net/20.500.14352/1044122024 Acuerdos transformativos CRUEAlpha-Gal/α-Gal is an oligosaccharide produced by non-primate mammals. Humans have developed an immune response mediated by anti-α-Gal antibodies that can trigger an allergic reaction and cause anaphylaxis. In recent years, cases of patients with delayed allergic reaction to mammalian meat have been reported worldwide. In Spain, these cases have been related to the species Ixodes ricinus L. (Ixodida: Ixodidae), whose distribution is located in the north of the country. In this work, the presence of α-Gal in water-soluble extracts from samples of salivary glands and digestive tracts of Hyalomma lusitanicum Koch (Ixodida: Ixodidae) both engorged and collected from vegetation were studied. The presence of that epitope was confirmed by the presence of reactive proteins of >250 kDa in both samples. The highest concentrations of α-Gal were detected in salivary glands. Neither sex nor diet influenced the concentration of α-Gal, which seems to indicate its endogenous production and its possible inoculation to the host during tick feeding.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article1365-2915https://doi.org/10.1111/mve.12724https://pubmed.ncbi.nlm.nih.gov/38741222/open access576.8Alpha-Gal epitopeDigestive tractHyalomma lusitanicumMediterranean ticksRed meat allergySalivary glandsTick-induced allergyParasitología (Farmacia)3207.12 Parasitología