Demelo Rodríguez, PabloCervilla Muñoz, EvaOrdieres Ortega, LucíaParra Virto, A.Toledano Macías, M.Toledo Samaniego, N.García García, A.García-Fernández-Bravo, I.Ji, Z.Miguel Díez, Javier DeÁlvarez-Sala Walther, Luis AntonioToro Cervera, Jorge DelGaleano Valle, Francisco2025-12-192025-12-192020-0929. Demelo-Rodríguez P, Cervilla-Muñoz E, Ordieres-Ortega L, Parra-Virto A, Toledano-Macías M, Toledo-Samaniego N, García-García A, García-Fernández-Bravo I, Ji Z, de-Miguel-Diez J, Álvarez-Sala-Walther LA, del-Toro-Cervera J, Galeano-Valle F. Incidence of asymptomatic deep vein thrombosis in patients with COVID-19 pneumonia and elevated D-dimer levels. Thromb Res. 2020 Aug;192:23-26. doi: 10.1016/j.thromres.2020.05.018. Epub 2020 May 13.0049-384810.1016/j.thromres.2020.05.018https://hdl.handle.net/20.500.14352/129432Aim An increased risk of venous thromboembolism (VTE) in patients with COVID-19 pneumonia admitted to intensive care unit (ICU) has been reported. Whether COVID-19 increases the risk of VTE in non-ICU wards remains unknown. We aimed to evaluate the burden of asymptomatic deep vein thrombosis (DVT) in COVID-19 patients with elevated D-dimer levels. Method In this prospective study consecutive patients hospitalized in non-intensive care units with diagnosis of COVID-19 pneumonia and D-dimer > 1000 ng/ml were screened for asymptomatic DVT with complete compression doppler ultrasound (CCUS). The study was approved by the Institutional Ethics Committee. Results The study comprised 156 patients (65.4% male). All but three patients received standard doses of thromboprophylaxis. Median days of hospitalization until CCUS was 9 (IQR 5–17). CCUS was positive for DVT in 23 patients (14.7%), of whom only one was proximal DVT. Seven patients (4.5%) had bilateral distal DVT. Patients with DVT had higher median D-dimer levels: 4527 (IQR 1925-9144) ng/ml vs 2050 (IQR 1428-3235) ng/ml; p < 0.001. D-dimer levels > 1570 ng/ml were associated with asymptomatic DVT (OR 9.1; CI 95% 1.1–70.1). D-dimer showed an acceptable discriminative capacity (area under the ROC curve 0.72, 95% CI 0.61–0.84). Conclusion In patients admitted with COVID-19 pneumonia and elevated D-dimer levels, the incidence of asymptomatic DVT is similar to that described in other series. Higher cut-off levels for D-dimer might be necessary for the diagnosis of DVT in COVID-19 patients.engjournal articlehttps://doi.org/10.1016/j.thromres.2020.05.018https://www.sciencedirect.com/science/article/pii/S0049384820301900?via%3Dihubrestricted access616.15-005.6616.98:578.834COVID-19SARS-CoV-2 infectionVenous thromboembolismDeep vein thrombosisD-dimerDoppler ultrasoundCiencias Biomédicas32 Ciencias Médicas