Fernández Lucas, Alberto AmableLópez-Ibor Alcocer, María InésTurrero Nogués, AgustínSantos García, Juan MatíasMorón, María DoloresHornero, RobertoGómez, CarlosMéndez, María AndreinaOrtiz Alonso, TomásLópez-Ibor Aliño, Juan José2023-06-202023-06-202011-11Fernández, A. A., López Ibor, M. I., Turrero, A. et al. «Lempel–Ziv Complexity in Schizophrenia: A MEG Study». Clinical Neurophysiology, vol. 122, n.o 11, noviembre de 2011, pp. 2227-35. DOI.org (Crossref), https://doi.org/10.1016/j.clinph.2011.04.011.1388-245710.1016/j.clinph.2011.04.011https://hdl.handle.net/20.500.14352/44635Objective: The neurodevelopmental-neurodegenerative debate is a basic issue in the field of the neuropathological basis of schizophrenia (SCH). Neurophysiological techniques have been scarcely involved in such debate, but nonlinear analysis methods may contribute to it. Methods: Fifteen patients (age range 23-42. years) matching DSM IV-TR criteria for SCH, and 15 sex- and age-matched control subjects (age range 23-42. years) underwent a resting-state magnetoencephalographic evaluation and Lempel-Ziv complexity (LZC) scores were calculated. Results: Regression analyses indicated that LZC values were strongly dependent on age. Complexity scores increased as a function of age in controls, while SCH patients exhibited a progressive reduction of LZC values. A logistic model including LZC scores, age and the interaction of both variables allowed the classification of patients and controls with high sensitivity and specificity. Conclusions: Results demonstrated that SCH patients failed to follow the " normal" process of complexity increase as a function of age. In addition, SCH patients exhibited a significant reduction of complexity scores as a function of age, thus paralleling the pattern observed in neurodegenerative diseases. Significance: Our results support the notion of a progressive defect in SCH, which does not contradict the existence of a basic neurodevelopmental alteration.engjournal articlehttps//doi.org/10.1016/j.clinph.2011.04.011http://www.sciencedirect.com/science/article/pii/S1388245711002689http://oa.upm.es/13661/2/INVE_MEM_2011_114917.pdfhttp://www.sciencedirect.com/open accessLempel-Ziv complexityMagnetoencephalographyNeurodegenerativeNeurodevelopmentalSchizophrenia. EMTREE medical terms: adultAgeArticleClinical articleControlled studyCorrelation analysisFemaleHumanLempel ziv complexity scoreLogistic regression analysisMagnetoencephalographyMalePatient codingPriority journalSchizophreniaScoring systemSensitivity and specificity.MeSH: AdultAgingCerebral CortexCognition DisordersDisease ProgressionFemaleHumansMaleSchizophreniaSchizophrenic PsychologySignal ProcessingComputer-AssistedYoung Adult