Garcillán Goyoaga, Beatriz deMarín Marín, Ana VictoriaJiménez Reinoso, AnaïsBriones Contreras, AlejandroMuñoz Ruiz, MiguelGarcía León, María JGil Calle, Juana NellyAllende Martínez, Luis MiguelMartínez Naves, EduardoToribio, Maria LuisaRegueiro González-Barros, José Ramón2023-06-182023-06-182015-06-251664-322410.3389/fimmu.2015.00020https://hdl.handle.net/20.500.14352/23905Human T cell receptor (TCR) immunodeficiencies (TCRID) are rare autosomal recessive disorders caused by mutations affecting TCR, CD3, or CD247 chains, which share developmental, functional, and TCR expression defects (1). Their rapid diagnosis is fundamental for patient survival and early hematopoietic stemcell transplantation.Here,we propose that studying gd T cells, which are often neglected, can be helpful for a timely diagnosis. We thus offer a diagnostic flowchart and some lab tricks based on published cases.engjournal articlehttps://doi.org/10.3389/fimmu.2015.00020open accessTCRimmunodeficiencydiagnosisgdT lymphocyteInmunología2412 Inmunología