Quignodon, LaureGrijota Martínez, María CarmenCompe, EmmanuelGuyot, RomainAllioli, NathalieLaperriere, DavidWalker, RobertMeltzer, PaulMader, SylvieSamarut, JacquesFlamant, Frédéric2024-01-092024-01-092007Quignodon, L., et al. «A Combined Approach Identifies a Limited Number of New Thyroid Hormone Target Genes in Post-Natal Mouse Cerebellum». Journal of Molecular Endocrinology, vol. 39, n.o 1, julio de 2007, pp. 17-28. DOI.org (Crossref), https://doi.org/10.1677/JME-06-0054.0952-504110.1677/jme-06-0054https://hdl.handle.net/20.500.14352/92094Thyroid hormones act directly on gene transcription in the post-natal developing cerebellum, controlling neuronal, and glial cell differentiation. We have combined three experimental approaches to identify the target genes that are underlying this phenomenon: 1) a microarray analysis of gene expression to identify hormone responsive genes in the cerebellum of Pax8-/- mice, a transgenic mouse model of congenital hypothyroidism; 2) a similar microarray analysis on primary culture of cerebellum neurons; and 3) a bioinformatics screen of conserved putative-binding sites in the mouse genome. This identifies surprisingly a small set of target genes, which, for some of them, might be key regulators of cerebellum development and neuronal differentiation.engjournal article1479-6813https://doi.org/10.1677/JME-06-0054open access577.17612.8616.4Biología celular (Biología)Bioquímica (Biología)Neurociencias (Biológicas)2407 Biología Celular2403 Bioquímica2490 Neurociencias