Salinero Fort, Miguel ÁngelSan Andrés Rebollo, Francisco JavierCárdenas Valladolid, JuanMéndez Bailón, ManuelChico Moraleja, R. M.Carrillo de Santa Pau, EnriqueJiménez Trujillo, María IsabelGómez Campelo, I.De Burgos Lunar, CarmenMiguel Yanes, José María DeMADIABETES2024-01-122024-01-122021-07-27Salinero-Fort MA, Andrés-Rebollo FJS, Cárdenas-Valladolid J, Méndez-Bailón M, Chico-Moraleja RM, de Santa Pau EC, Jiménez-Trujillo I, Gómez-Campelo I, de Burgos Lunar C, de Miguel-Yanes JM; MADIABETES. Cardiovascular risk factors associated with acute myocardial infarction and stroke in the MADIABETES cohort. Sci Rep. 2021 Jul 27;11(1):15245. Erratum in: Sci Rep. 2022 Apr 8;12(1):594510.1038/s41598-021-94121-8https://hdl.handle.net/20.500.14352/92802We aimed to develop two models to estimate first AMI and stroke/TIA, respectively, in type 2 diabetes mellitus patients, by applying backward elimination to the following variables: age, sex, duration of diabetes, smoking, BMI, and use of antihyperglycemic drugs, statins, and aspirin. As time-varying covariates, we analyzed blood pressure, albuminuria, lipid profile, HbA1c, retinopathy, neuropathy, and atrial fibrillation (only in stroke/TIA model). Both models were stratified by antihypertensive drugs. We evaluated 2980 patients (52.8% women; 67.3 ± 11.2 years) with 24,159 person-years of follow-up. We recorded 114 cases of AMI and 185 cases of stroke/TIA. The factors that were independently associated with first AMI were age (≥ 75 years vs. < 75 years) (p = 0.019), higher HbA1c (> 64 mmol/mol vs. < 53 mmol/mol) (p = 0.003), HDL-cholesterol (0.90-1.81 mmol/L vs. < 0.90 mmol/L) (p = 0.002), and diastolic blood pressure (65-85 mmHg vs. < 65 mmHg) (p < 0.001). The factors that were independently associated with first stroke/TIA were age (≥ 75 years vs. < 60 years) (p < 0.001), atrial fibrillation (first year after the diagnosis vs. more than one year) (p = 0.001), glomerular filtration rate (per each 15 mL/min/1.73 m2 decrease) (p < 0.001), total cholesterol (3.88-6.46 mmol/L vs. < 3.88 mmol/L) (p < 0.001), triglycerides (per each increment of 1.13 mmol/L) (p = 0.031), albuminuria (p < 0.001), neuropathy (p = 0.01), and retinopathy (p = 0.023).engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article2045-2322https://pubmed.ncbi.nlm.nih.gov/34315938/open access616.1/.9Medicina interna3205 Medicina Interna