Zahran, FouadMarzal, PabloRuiz Saldaña, Helga KarinaPérez Velilla, EduardoCalvo Garrido, María LourdesCabañas Poveda, Albertina2024-10-162024-10-162024https://doi.org/10.1016/j.supflu.2024.106413https://hdl.handle.net/20.500.14352/108991Ciprofloxacin is a broad-spectrum antibiotic that is proposed for pulmonary administration. In this work micronization of ciprofloxacin was performed by the Supercritical Antisolvent Technique (SAS) using ciprofloxacin base (CIP) in ethanol/acetic acid and ciprofloxacin hydrochloride salt (CIP·HCl ) in methanol at 40-60 ºC and 100-150 bar. Yields ranged from 40-90 %. CIP precipitated incorporating acetate whilst CIP·HCl precipitated as the AH1 anhydrous form. CIP and CIP·HCl particles exhibited an acicular morphology (0.2-0.9 μm wide x 1-4 μm long). Micronization adding lactose, PVP K-10 and K 30 did not change the crystalline form but modified the precipitate morphology. CIP·HCl:lactose and CIP·HCl:PVP K-30 at a 4:1 drug:excipient mass ratio precipitated like flakes. CIP·HCl:PVP K-10 precipitated as submicron globular particles suitable for oral formulation. Increasing the PVP content, the morphology changed to sheets and flakes, which could be used for pulmonary administration. The antibacterial activity of the samples for Staphylococcus epidermidis was confirmed.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.1016/j.supflu.2024.106413https://www.sciencedirect.com/science/article/pii/S0896844624002481open access544Drug deliverySupercritical CO2Supercritical fluidsMicronizationAntisolventCienciasQuímica23 Química2210 Química Física3209 Farmacología