Pascual Mancho, JaraPintado Recarte, María Del PilarRomero Román, CarlosMorales Camino, Jorge C.Hernández Martín, ConcepciónBujan, JuliaOrtega, Miguel A.De León Luis, Juan Antonio2023-06-172023-06-172021-06-042075-441810.3390/diagnostics11061036https://hdl.handle.net/20.500.14352/7408This study (FIS-PI18/00912) was supported by the Instituto de Salud Carlos III (Plan Estatal de I+D+i 2013–2016) and co-financed by the European Development Regional Fund ‘‘A way to achieve Europe’’ (ERDF) and B2017/BMD-3804 MITIC-CM and the Maternal-fetal medicine research grant (Santiago Dexeus Font Foundation).Fetal growth restriction (FGR) is one of the most important obstetric pathologies. It is frequently caused by placental insufficiency. Previous studies have shown a relationship between FGR and impaired new-born neurodevelopment, although the molecular mechanisms involved in this association have not yet been completely clarified. Reelin is an extracellular matrix glycoprotein involved in development of neocortex, hippocampus, cerebellum and spinal cord. Reelin has been demonstrated to play a key role in regulating perinatal neurodevelopment and to contribute to the emergence and development of various psychiatric pathologies, and its levels are highly influenced by pathological conditions of hypoxia. The purpose of this article is to study whether reelin levels in new-borns vary as a function of severity of fetal growth restriction by gestational age and sex. We sub-grouped fetuses in: normal weight group (Group 1, n = 17), FGR group with normal umbilical artery Doppler and cerebral redistribution at middle cerebral artery Doppler (Group 2, n = 9), and FGR with abnormal umbilical artery Doppler (Group 3, n = 8). Our results show a significant association of elevated Reelin levels in FGR fetuses with cerebral blood redistribution compared to the normal weight group and the FGR with abnormal umbilical artery group. Future research should focus on further expanding the knowledge of the relationship of reelin and its regulated products with neurodevelopment impairment in new-borns with FGR and should include larger and more homogeneous samples and the combined use of different in vivo techniques in neonates with impaired growth during their different adaptive phases.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/journal articlehttps://doi.org/10.3390/diagnostics11061036https://www.mdpi.com/2075-4418/11/6/1036open access618.2Intrauterine growth restrictionPerinatal neurodevelopmentReelinhypoxiaMedicinaGinecología y obstetriciaSalud pública (Medicina)32 Ciencias Médicas3201.08 Ginecología3212 Salud Pública