Antón Hurtado, Olga MaríaPeterson, MaryHollander, MichaelDorward, DavidArora, GunjanTraba, JavierRajagopalan, SumatiSnapp, ErikGarcia, ChristopherWaldmann, ThomasLong, Eric2024-01-312024-01-312019Anton, Olga M., et al. «Trans -Endocytosis of Intact IL-15Rα–IL-15 Complex from Presenting Cells into NK Cells Favors Signaling for Proliferation». Proceedings of the National Academy of Sciences, vol. 117, n.o 1, enero de 2020, pp. 522-31. https://doi.org/10.1073/pnas.1911678117.0027-842410.1073/pnas.1911678117https://hdl.handle.net/20.500.14352/96970Interleukin 15 (IL-15) is essential for natural killer (NK) cell survival and proliferation. The IL-15 receptor consists of 3 subunits: the α chain and the β and common γ chains, which are shared with the IL-2 receptor. NK cells express the β-γchains and are activated in trans by cells presenting IL-15 bound to IL-15Rα, such as dendritic cells. We show here that the release of soluble IL-15Rα–IL-15 complex from presenting cells contributes to efficient signaling for NK cell survival, whereas uptake of the entire membrane-associated-IL-15Rα–IL-15 complex from presenting cells into NK cells contributes to proliferation. Thus, outcomes are dictated not only by signal strength, but also by location where IL-15 trans-presentation occurs in NK cells.engjournal article1091-6490https://doi.org/10.1073/pnas.1911678117restricted accessBiología molecular (Biología)2412.07 Inmunoquímica