Fernández, AlbertoTurrero, AgustínZuluaga Arias, PilarGil, PedroMaestú Unturbe, FernandoCampo, PabloOrtiz, Tomás2023-06-202023-06-202006-030003-994210.1001/archneur.63.3.427https://hdl.handle.net/20.500.14352/51431Background: Subjects with mild cognitive impairment (MCI) are at a higher risk of experiencing Alzheimer disease (AD). Magnetoencephalographic temporoparietal dipole densities of low-frequency activity are good predictors of individuals' cognitive status, and might be a useful tool to investigate the conversion from MCI to AD. Objective: To investigate the role of low-frequency dipole densities as predictors of the risk of developing AD. Design: Whole-head magnetoencephalographic recordings were obtained from 19 probable AD patients, 17 MCI patients, and 17 healthy control subjects. The generators of focal magnetic slow waves were located using a single moving dipole model. Results: Left parietal δ dipole density permitted a reliable classification of AD and MCI patients. The MCI patients were divided into 2 groups based on the median left parietal δ dipole density, and were followed up for 2 years. The estimated relative risk of conversion to AD was increased by 350% in those MCI patients with high left parietal δ dipole density scores. Conclusions: Results confirmed the important role of parietal δ dipole density in the evaluation of AD and MCI. A magnetoencephalographic-based assessment of AD and MCI patients might be considered a useful clinical test in the near future.journal articlehttp://archneur.jamanetwork.com/article.aspx?articleid=790798metadata only access51-76EMTREE medical terms: agedAlzheimer diseasearticleclinical articlecognitive defectcontrolled studydensitydipoledisease classificationfollow uphealth statushumanmagnetoencephalographymild cognitive impairmentpredictionpriority journalrisk factorscoring systemwaveform MeSH: AgedAged80 and overAlzheimer DiseaseBrain MappingCase-Control StudiesCognition DisordersFemaleFollow-Up StudiesHumansLogistic ModelsMagnetoencephalographyMaleMental Status ScheduleNeuropsychological TestsParietal LobeRiskEstadística aplicadaBiología24 Ciencias de la Vida