Durán Sampedro, GonzaloEpelde Elezcano, NereaMartínez Martínez, VirginiaEsnal Martínez, IxoneBañuelos Prieto, JorgeGarcía Moreno, InmaculadaRodríguez Agarrabeitia, AntoniaMoya Cerero, Santiago de laTabero Truchado, AndreaLázaro Carrillo, AnaVillanueva Oroquieta, ÁngelesOrtiz García, María JosefaLópez Arbeloa, Íñigo María2023-06-172023-06-172017-07-010143-720810.1016/j.dyepig.2017.03.026https://hdl.handle.net/20.500.14352/18152Received 30 January 2017, Revised 10 March 2017, Accepted 11 March 2017, Available online 12 March 2017.Despite fluorescent photodynamic therapy (fluorescent-PDT) dyes are promising theranostic agents, current approaches unfortunately involve crucial shortcomings (such as, narrow absorption bands, high cost, low bio-compatibility and specificity, low dual efficiency) making difficult their clinical translation. Particularly, efficient fluorescent-PDT agents triggered under white-light, with potential application in topic solar treatments, are scarce. Here, we describe the rational development of a novel fluorescent-PDT molecular biomaterial based on BODIPY building blocks able to sustain, simultaneously, synthetic accessibility, high fluorescence and phototoxicity within a broad spectral window, biocompatibility, including low dark toxicity and high cell permeability with selective accumulation in lysosomes and, what is more important, excellent efficient activity triggered under white light. These all-in-one combined properties make the new dye a valuable ground platform for the development of future smarter theranostic agents.engjournal articlehttp://dx.doi.org/10.1016/j.dyepig.2017.03.026restricted access543.426547.1535.37:61-07BODIPY dyesPhotosensitizersSinglet oxygenTheragnosisWhite lightPhotodynamic therapyFísica (Química)MaterialesQuímica orgánica (Química)Bioquímica (Biología)3312 Tecnología de Materiales2306 Química Orgánica2302 Bioquímica