Guerra Pérez, NataliaRamos, EdurneGarcía-Hernández, MartaPinto, CeliaSoto, ManuelMartín, ElenaGonzález, Victor Manuel2024-02-012024-02-012015Guerra-Pérez N, Ramos E, GarcíaHernández M, Pinto C, Soto M, Martín ME, et al. (2015) Molecular and Functional Characterization of ssDNA Aptamers that Specifically Bind Leishmania infantum PABP. PLoS ONE 10(10): e01400481932-620310.1371/journal.pone.0140048https://hdl.handle.net/20.500.14352/97881A poly (A)-binding protein from Leishmania infantum (LiPABP) has been recently cloned and characterized in our laboratory. Although this protein shows a very high homology with PABPs from other eukaryotic organisms including mammals and other parasites, exist divergences along the sequence that convert them in potential diagnostic markers and/or therapeutics targets. Aptamers are oligonucleotide ligands that are selected in vitro by their affinity and specificity for the target as a consequence of the particular tertiary structure that they are able to acquire depending on their sequence. Development of high-affinity molecules with the ability to recognize specifically Leishmania proteins is essential for the progress of this kind of study.engAttribution-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nd/4.0/journal articlehttps://doi.org/10.1371/journal.pone.014004826457419open access577.2577.21ssDNALeishmania infantumCiencias Biomédicas24 Ciencias de la Vida