García Esteban, María TeresaPelaz, C.Giménez, M.J.Aguilar, L.2025-10-282025-10-282000García, M. T., et al. «In Vitro Activities of Gemifloxacin versus Five Quinolones and Two Macrolides against 271 Spanish Isolates of Legionella Pneumophila : Influence of Charcoal on Susceptibility Test Results». Antimicrobial Agents and Chemotherapy, vol. 44, n.o 8, agosto de 2000, pp. 2176-78. DOI.org (Crossref), https://doi.org/10.1128/AAC.44.8.2176-2178.2000.0066-480410.1128/AAC.44.8.2176-2178.2000https://hdl.handle.net/20.500.14352/125468This study was supported by a grant from SmithKline Beecham Pharmaceuticals, Harlow, United Kingdom.The MICs at which 90% of isolates are inhibited for gemifloxacin, trovafloxacin, and grepafloxacin were low (≤0.01 μg/ml) for 271Legionella isolates when they were determined by the broth microdilution method but increased (≥6 dilutions) when they were determined by the agar dilution method. This was due to the charcoal in the agar dilution medium, as shown by the progressive decrease in the MICs when the charcoal concentrations decreased. As free drug is the active fraction, charcoal binding should be considered.engjournal articlehttps://doi.org/10.1128/aac.44.8.2176-2178.2000https://journals.asm.org/doi/10.1128/aac.44.8.2176-2178.2000restricted access615.33579.841.9579.24616.98Farmacología (Medicina)Microbiología médicaQuímica analítica (Farmacia)2414 Microbiología3209 Farmacología2301 Química Analítica