San Román, JesusCarricondo Orejana, Francisco JavierIglesias Moreno, María CruzMartín-Villares, CristinaPoch Broto, JoaquínGil Loyzaga, Pablo2024-01-172024-01-172012-09-01San Román, J., Carricondo, F., Iglesias-Moreno, M. C., Martín-Villares, C., Poch-Broto, J., & Gil-Loyzaga, P. (2012). Electrophysiological monitoring of hearing function during cochlear perilymphatic perfusions. Acta oto-laryngologica, 132(9), 916–922. https://doi.org/10.3109/00016489.2012.6789450001-648910.3109/00016489.2012.678945https://hdl.handle.net/20.500.14352/93504Conclusion: The cochlear perilymphatic perfusion produces, by itself, significant effects in the cochlear physiology that could be associated with the surgical procedure. These effects need to be well characterized to allow a reliable quantification of the effects of the experimental agent being tested. Objectives: The study focused on the accurate description of the electrophysiological effects on the cochlear potential recordings of perilymphatic perfusions. Methods: Two successive cochlear perilymphatic perfusions were carried out. The first used artificial perilymph. The second used artificial perilymph alone or a kainic acid (KA) solution in artificial perilymph. The compound action potential of the auditory nerve (CAP-AN) was recorded: (1) before the first perfusion, (2) after the first perfusion and (3) after the second perfusion, and compared between groups. Results: The first intracochlear perfusion with artificial perilymph produced significant effects in the CAP-AN that could be related to the surgical procedure. These effects were analysed separately from the effects produced by the KA. In particular, the KA administered intracochlearly produced a significant increase in the latency and a decrease in the amplitude of the CAP-AN N1 wave compared with the controls that were perfused twice with artificial perilymph.engjournal article1651-2251https://www.tandfonline.com/doi/full/10.3109/00016489.2012.67894522667457https://www.tandfonline.com/journals/ioto20open access616.21Hypoacusiaexcitotoxic amino acidsratkainic acidcochlear decompressioncochlear evoked potentialscompound action potential of the auditory nerveelectrocochleographyartificial perilymphNeurociencias (Biológicas)FisiologíaOtorrinolaringología2411.13 Fisiología de la Audición