Cores Esperón, ÁngelPiquero Martí, MartaVillacampa Sanz, MercedesLeón Martínez, RafaelMenéndez Ramos, José Carlos2023-06-172023-06-172020-06-142218-273X10.3390/biom10060904https://hdl.handle.net/20.500.14352/8385NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.engAtribución 3.0 Españajournal articlehttps://doi.org/10.3390/biom10060904https://www.mdpi.com/2218-273X/10/6/904open accessNRF2–ARE pathwayneurodegenerative diseasesoxidative stressKEAP1NRF2 regulationNeurociencias (Farmacia)2490 Neurociencias