Alou Cervera, LuisCafini, FabioSevillano Fernández, DavidUnzueta, IrunePrieto Prieto, José2024-07-232024-07-232004-05Alou L, Cafini F, Sevillano D, Unzueta I, Prieto J. In vitro activity of mupirocin and amoxicillin-clavulanate alone and in combination against staphylococci including those resistant to methicillin. Int J Antimicrob Agents. 2004 May;23(5):513-6.0924-857910.1016/j.ijantimicag.2003.09.030https://hdl.handle.net/20.500.14352/107056Mupirocin and amoxicillin-clavulanate were synergistic against 9 of 49 (18%) strains of methicillin-resistant and methicillin-susceptible Staphylococcus aureus and coagulase-negative staphylococci (CNS). A pattern of enhanced killing was also found using time-kill studies. Time-kill assays were more discriminatory than chequerboard titration assays in demonstrating synergy. These results suggest that combinations of amoxicillin-clavulanate and mupirocin may have therapeutic benefits in prophylaxis against staphylococcal infections.engjournal articlehttps://doi.org/10.1016/j.ijantimicag.2003.09.030https://www.sciencedirect.com/science/article/pii/S0924857904000482restricted access611.02ProphylaxisCathetersVascular-graft infectionMicrobiología médica2414 Microbiología