Abad Martínez, María JoséBermejo Benito, PaulinaÁlvarez, MariaGuerra Guirao, José AntonioSilván, Ana MaríaVillar Del Fresno, Ángel2026-03-172026-03-172004Flavonoids and a Sesquiterpene Lactone from Tanacetum microphyllum Inhibit Anti-Inflammatory Mediators in LPS-Stimulated Mouse Peritoneal Macrophages. Planta med. enero de 2004;70(1):34-8. doi:10.1055/s-2004-81545210.1055/S-2004-815452https://hdl.handle.net/20.500.14352/134062In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3′-dihydroxy-4′-methoxy-7- methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibitors of some macrophage functions involved in the inflammatory process. These five compounds significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) in a concentration-dependent manner. In the tumour necrosis factor-α (TNF-α) assay, only centaureidin and hydroxyachillin significantly inhibited the accumulation of TNF-α. These results indicate that these compounds may contribute to the anti-inflammatory properties of T. microphyllum.engjournal articlehttps://doi.org/10.1055/S-2004-815452restricted access615.4Tanacetum microphyllumCompositaelipopolysaccharideprostaglandin E2nitric oxideumour necrosis factor-αFarmacología (Farmacia)3209.90 Farmacología Experimental3209.07 Fitofármacos