Barrio, Manuel deTornero Molina, PilarPrieto, A.Sainza, T.Zubeldia Ortuño, José ManuelHerrero, T.2024-01-292024-01-291997-05-01de Barrio M, Tornero P, Prieto A, Sainza T, Zubeldia JM, Herrero T. Recurrent fixed drug eruption caused by citiolone. J Investig Allergol Clin Immunol. 1997 May-Jun;7(3):193-4. PMID: 9252880.1018-9068https://hdl.handle.net/20.500.14352/95775Citiolone (N-acetylhomocysteinethiolactone) is a thiolic­derived medication frequently used in Spain and in other countries as a mucolytic agent for the treatment of certain hepatic disorders. Mucolytic drugs have rarely been implicated in the fixed drug eruption etiology. We report on a patient who presented several episodes of fixed exanthema related to citiolone intake. The patch test with citiolone (10% in dimethyl sulfoxide) was negative. The diagnosis was confirmed by a positive controlled oral challenge test. Other mucolytic thiolic­derivatives (N-acetylcysteine) were tolerated by the patient, thus crossreactivity between these drugs seems to be unlikely.engjournal article1698-08089252880https://pubmed.ncbi.nlm.nih.gov/9252880/restricted access616-056.3Fixed drug eruptionCitioloneCrossreactivityMucolytic thiolic-derivativesN-acetylcysteineCiencias Biomédicas32 Ciencias Médicas