Paraquat Treatment Compromises the Clearance of β-Amyloid and Tau Proteins and Induces Primary Hippocampal Neuronal Cell Death through HSP70, P20S, and TFEB Disruption

Moyano-Cires Ivanoff, Paula VivianaGarcía Sánchez, José ManuelGarcía Lobo, JimenaFrejo Moya, María TeresaNaval López, María VictoriaPino Sans, Javier DelSanjuna, Javier2025-01-282025-01-282020Paula Moyano, Javier Sanjuna, José Manuel Garcia, Jimena Garcia, María Teresa Frejo, María Victoria Naval, and Javier del Pino Chemical Research in Toxicology 2021 34 (5), 1240-1244 DOI: 10.1021/acs.chemrestox.0c0037010.1021/acs.chemrestox.0c00370.https://hdl.handle.net/20.500.14352/116568The herbicide paraquat (PQ) induces hippocampal neuronal cell loss and cognitive dysfunction after one and repeated treatment. All the mechanisms involved in these effects are not well understood. Single and repeated PQ treatment increased Aβ and tau protein levels, through HSP70 and TFEB downregulation and proteasome 20S inhibition, producing cell death in primary hippocampal neurons associated with cognitive decline. Our results reveal the mechanisms through which PQ could induce the accumulation of abnormal proteins and neurodegeneration that could originate the cognitive decline produced by it and could help managing its degenerative effects.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalcreativecommons.org/licenses/by/4.0/Paraquat Treatment Compromises the Clearance of β-Amyloid and Tau Proteins and Induces Primary Hippocampal Neuronal Cell Death through HSP70, P20S, and TFEB Disruptionjournal articlehttps://dx.doi.org/10.1021/acs.chemrestox.0c00370restricted access615.9612.8NeurotoxicologíaProteínasGeneticsInhibitionOxidative stressPeptides and proteinsProtein dynamicsRodent modelsToxicología (Medicina)Neurociencias (Farmacia)3214 Toxicología3205.07 Neurología