Colilla Nieto, MontserratIzquierdo Barba, IsabelVallet Regí, María Dulce Nombre2023-06-172023-06-172018-11-222305-632010.3390/medicines5040125https://hdl.handle.net/20.500.14352/12935RESEARCHER ID N-4628-2014 (Montse Colilla Nieto) ORCID 0000-0003-1961-4160 (Montse Colilla Nieto) RESEARCHER ID M-9921-2014 (Isabel Izquierdo Barba) ORCID 0000-0002-4139-4646 (Isabel Izquierdo Barba) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí)Zwitterionization of biomaterials has been heightened to a potent tool to develop biocompatible materials able to inhibit bacterial and non-specific proteins adhesion. This constitutes a major progress in the biomedical field. This manuscript overviews the main functionalization strategies that have been reported up to date to design and develop these advanced biomaterials. On this regard, the recent research efforts dedicated to provide their surface of zwitterionic nature are summarized by classifying biomaterials in two main groups. First, we centre on biomaterials in clinical use, concretely bioceramics and metallic implants. Finally, we revise emerging nanostructured biomaterials, which are receiving growing attention due to their multifunctionality and versatility mainly in the local drug delivery and bone tissue regeneration scenarios.engAtribución 3.0 Españajournal articlehttps://doi.org/10.3390/medicines5040125http://www.ucm.es/valletregigrouphttps://www.mdpi.com/2305-6320/5/4/125open accessBiomaterialszwitterionic surfacesinfectionbioceramicsbacterial inhibition.Materiales3312 Tecnología de Materiales