Moreno, LaraCheng, WangSviatlana, LamakaZheludkevich, Mikhail L.Rodríguez Hernández, JuanArrabal Durán, RaúlMatykina, Endzhe2024-10-212024-10-212023: Moreno, L.; Wang, C.; Lamaka, S.V.; Zheludkevich, M.L.; Rodríguez-Hernández, J.; Arrabal, R.; Matykina, E. Ciprofloxacin Release and Corrosion Behaviour of a Hybrid PEO/PCL Coating on Mg3Zn0.4Ca Alloy. J. Funct. Biomater. 2023, 14, 6510.3390/jfb14020065https://hdl.handle.net/20.500.14352/109124In the present work, a hybrid hierarchical coating (HHC) system comprising a plasma electrolytic oxidation (PEO) coating and a homogeneously porous structured polycaprolactone (PCL) top-coat layer, loaded with ciprofloxacin (CIP), was developed on Mg3Zn0.4Ca alloy. According to the findings, the HHC system avoided burst release and ensured gradual drug elution (64% over 240 h). The multi-level protection of the magnesium alloy is achieved through sealing of the PEO coating pores by the polymer layer and the inhibiting effect of CIP (up to 74%). The corrosion inhibition effect of HHC and the eluted drug is associated with the formation of insoluble CIP-Me (Mg/Ca) chelates that repair the defects in the HHC and impede the access of corrosive species as corroborated by FTIR spectra, EIS and SEM images after 24 h of immersion. Therefore, CIP participates in an active protection mechanism by interacting with cations coming through the damaged coatingengAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal articlehttps://doi.org/10.3390/jfb14020065https://www.mdpi.com/2079-4983/14/2/65open access620Corrosion inhibitorDrug deliveryHybrid hierarchical coatingsOrthopaedicMagnesiumPlasma electrolytic oxidationPolycaprolactoneMateriales3312 Tecnología de Materiales3303 Ingeniería y Tecnología Químicas