Lagunas García, Luisa NataliaMarraudino, MarilenaAmorim, Miguel dePinos, HelenaCollado, PalomaPanzica, GianCarloGarcia-Segura, LuisGrassi, Daniela2024-01-242024-01-242019Lagunas, Natalia, et al. «Estrogen Receptor Beta and G Protein-Coupled Estrogen Receptor 1 Are Involved in the Acute Estrogenic Regulation of Arginine-Vasopressin Immunoreactive Levels in the Supraoptic and Paraventricular Hypothalamic Nuclei of Female Rats». Brain Research, vol. 1712, junio de 2019, pp. 93-100. https://doi.org/10.1016/j.brainres.2019.02.002.0006-899310.1016/j.brainres.2019.02.002https://hdl.handle.net/20.500.14352/95192The ovarian hormone 17β-estradiol is known to regulate the release, expression and immunoreactivity of arginine-vasopressin (AVP) in the supraoptic and paraventricular hypothalamic nuclei of rodents. Previous studies have shown that estrogen receptor α is involved in the effects of chronic estradiol administration on arginine-vasopressin immunoreactivity in the female rat hypothalamus. In this study we have examined the effect of an acute administration of estradiol or specific agonists for estrogen receptors α, β and G protein-coupled estrogen receptor 1 on the immunoreactivity of arginine-vasopressin in the hypothalamus of adult ovariectomized female rats. Acute estradiol administration resulted in a significant decrease in the number of arginine-vasopressin immunoreactive neurons in the supraoptic and paraventricular nuclei after 24 h. The effects of the specific estrogen receptors agonists suggest that the action of estradiol on arginine-vasopressin immunoreactivity is mediated in the supraoptic nucleus by G protein-coupled estrogen receptor 1 and in the paraventricular nucleus by both estrogen receptor β and G protein-coupled estrogen receptor 1. Thus, in contrast to previous studies on the effect of chronic estrogenic treatments, the present findings suggest that estrogen receptor β and G protein-coupled estrogen receptor 1 mediate the acute effects of estradiol on arginine-vasopressin immunoreactivity in the hypothalamus of ovariectomized rats.engjournal articlehttps://www.doi.org/10.1016/j.brainres.2019.02.002https://www.sciencedirect.com/science/article/pii/S0006899319300708?via%3Dihubrestricted access611.8117β-estradiolDPNG1GPERHypothalamusPPTNeurociencias (Biológicas)2490 Neurociencias