Merino Martín, José JoaquínCabaña-Muñoz, María EugeniaParmigiani-Izquierdo, José MaríaCamacho Alonso, Fabio2025-01-272025-01-272019Cabaña-Muñoz, María Eugenia, et al. «Increased Systemic Malondialdehyde Levels and Decreased Mo/Co, Co/Fe2+ Ratios in Patients with Long-Term Dental Titanium Implants and Amalgams». Journal of Clinical Medicine, vol. 8, n.o 1, enero de 2019, p. 86. DOI.org (Crossref), https://doi.org/10.3390/jcm8010086.10.3390/jcm8010086https://hdl.handle.net/20.500.14352/116385Abstract Introduction: the biological safety of dental biomaterials has been questioned in human studies. Material and methods: Several heavy metals/oligoelements were compared by Inductive Coupled Mass Spectrometry (ICP-MS) in hair samples from 130 patients (n = 54 patients with long-term titanium dental implants and amalgams (A + I group), 51 patients with long-term dental amalgam alone (A group), as well as controls (n = 25: without dental materials) of similar age. All patients (except controls) had had titanium dental implants and/or dental amalgams for at least 10 years (average: 17). We evaluated whether A + I patients could present higher systemic malondialdehyde levels (MDA) as compared to the A group. Results: The A + I group have lower molybdenum levels (A + I) and reduced Mo/Co and Mo/Fe2+ ratios, which could predispose them to oxidative stress by raising MDA levels as compared to the A group alone; our findings suggest that higher Co levels could enhance oxidative stress in the A + I group. However, there were no differences on metals from titanium alloy (Ti-6Al), Cr from crowns or Hg2+, Sn, Zn2+, Cu2+ levels between the A + I and A groups. Conclusion: patients with long-term dental titanium and amalgams have systemic oxidative stress due to rising MDA levels and lower Mo/Co and Mo/Fe2+ ratios than those with amalgams alone.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal articlehttps://doi.org/10.3390/jcm8010086https://pubmed.ncbi.nlm.nih.gov/30642082/open access615.46616.314Estrés oxidativoMetales pesadosNeurotoxicologíatoxicology of heavy metalsoligoelementsMolybdenum (Mo), titanium (Ti)Mercury, lipoperoxides (MDA)Oxidative stressFree radicals and medicineDental amalgams and titanium implantsOdontología (Medicina)Implantes dentales32 Ciencias Médicas