Muñoz Sáez, EmmaMunck García, Estefanía deArahuetes Portero, Rosa MaríaVicente, FranciscaOrtiz López, Francisco JavierCantizani, JuanGómez Miguel, Begoña2023-06-182023-06-182015-04-230304-394010.1016/j.neulet.2015.03.010https://hdl.handle.net/20.500.14352/23381Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA.engjournal articlehttps://www.journals.elsevier.com/neuroscience-letters/restricted access577.2547.915SH-SY5YSphingosine-1-phosphateβ-N-methylamine-l-alanineNeuroprotectionGSK3BiologíaBiología molecular (Biología)24 Ciencias de la Vida2415 Biología Molecular