Roscales García, SilviaGarcía Csaky, Aurelio2025-01-162025-01-16201210.1021/ol300272jhttps://hdl.handle.net/20.500.14352/114679A new stereoselective tandem reaction consisting of the metal-free conjugate addition of boronic acids followed by an intramolecular ring opening of a cyclic acetal has been disclosed. Optically pure polysubstituted tetrahydropyrans have been synthesized diastereoselectively by this new reaction. Two new C–C bonds and up to three stereocenters are formed in a single step, allowing the generation of quaternary stereocenters.engjournal articlehttps://pubs.acs.org/doi/10.1021/ol300272jrestricted access547Química orgánica (Química)2306 Química Orgánica