Buendía, P.Ramírez, R.Aljama, P.Carracedo Añón, Julia MaríaLitwack, Gerald2026-02-062026-02-062016Buendía, P., Ramírez, R., Aljama, P., & Carracedo, J. (2016). Klotho prevents translocation of nfκb. En Vitamins & Hormones (Vol. 101, pp. 119-150). Elsevier. https://doi.org/10.1016/bs.vh.2016.02.00597801280481910083-672910.1016/bs.vh.2016.02.005https://hdl.handle.net/20.500.14352/131839This work was supported by Plan Nacional de I+D+i Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII)-Subdirección General de Evaluación, Fondos de desarrollo regional (FEDER) (PI12/01489 and PI14/00806); Junta de Andalucía Grants (P010-CTS-6337, P11-CTS-7352); and Fundación Nefrológica. J.C. was supported by a contract from Fundación de Investigaciones Biomédicas de Córdoba (Servicio Andaluz de Salud, Programa Nicolás Monardes). P.B. is fellow from Consejería de...Klotho protein is a β-glucuronidase capable of hydrolyzing steroid β-glucuronides. Two molecules are produced by the Klotho gene, a membrane bound form and a circulating form. This protein is recognized as an antiaging gene with pleiotropic functions. The activation of cellular systems is associated with the pathogenesis of several chronic and degenerative diseases associated with an inflammatory state. Inflammation is characterized by an activation of NFκB. Klotho suppresses nuclear factor NFκB activation and the subsequent transcription of proinflammatory genes. This review focuses on the current understanding of Klotho protein function and its relationship with NFκB regulation, emphasizing its potential involvement in the pathophysiologic process.engbook parthttps://doi.org/10.1016/bs.vh.2016.02.005metadata only access577.1612.017Chronic kidney diseaseFgf-23InflammationKlothoNfκbOxidative stressSenescenceBioquímica (Biología)Inmunología2403 Bioquímica2412 Inmunología