Cafini, FabioAguilar, LorenzoAlou Cervera, LuisGiménez, María JoséSevillano Fernández, DavidTorrico, MarthaGonzález Hidalgo, NataliaGranizo, Juan JoséMartín Herrero, José EmilioPrieto Prieto, José2024-07-292024-07-292008-02-26Cafini F, Aguilar L, Alou L, Giménez MJ, Sevillano D, Torrico M, González N, Granizo JJ, Martín-Herrero JE, Prieto J. Cidal activity of oral third-generation cephalosporins against Streptococcus pneumoniae in relation to cefotaxime intrinsic activity. Eur J Clin Microbiol Infect Dis. 2008 Aug;27(8):679-83.0934-972310.1007/s10096-008-0493-7https://hdl.handle.net/20.500.14352/107149This study explores the killing kinetics within 12 h of four oral third-generation cephalosporins against ten Streptococcus pneumoniae strains exhibiting cefotaxime minimum inhibitory concentrations (MICs) from 0.03 to 2 microg/ml. Killing curves were performed with concentrations achievable in serum after standard doses (0.015-4 microg/ml). Reductions of 90% were achieved with all compounds at serum-achievable concentrations for strains exhibiting cefotaxime MIC < or = 0.5 microg/ml. Against strains with cefotaxime MIC > or = 1 microg/ml, only cefditoren reached a 90% reduction with concentrations of 0.5-1 microg/ml doses. At 4 microg/ml, cefditoren and cefotaxime reached 99.9% reduction in seven of the ten strains studied. At serum-achievable concentrations, cefdinir and cefixime were not bactericidal against strains exhibiting cefotaxime MIC > or = 0.25 microg/ml and > or = 0.5 microg/ml, respectively. Cefditoren showed the best killing kinetic profiles and this observation may be important when choosing an oral third-generation cephalosporin as initial or sequential therapyengjournal article1435-4373https://doi.org/10.1007/s10096-008-0493-7https://link.springer.com/article/10.1007/s10096-008-0493-7restricted access611.02CeftriaxoneCefotaximeCefiximeCefpodoximeInitial InoculumMicrobiología médica2414 Microbiología