Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against Candida spp. Biofilm Infections

Benavent Núñez, CarlosTorrado Salmerón, Carlos FélixTorrado Durán, Santiago2023-06-172023-06-172021-04-221424-824710.3390/ph14050397https://hdl.handle.net/20.500.14352/7433The aim of this study was to improve the treatment of Candida albicans biofilms through the use of nystatin solid dispersions developed using maltodextrins as a hyperosmotic carrier. Characterization studies by differential scanning calorimetry, X-ray diffraction, dissolution studies, and particle size analysis were performed to evaluate changes in nystatin crystallinity. Antifungal activity and anti-biofilm efficacy were assessed by microbiological techniques. The results for nystatin solid dispersions showed that the enhancement of antifungal activity may be related to the high proportions of maltodextrins. Anti-biofilm assays showed a significant reduction (more than 80%) on biofilm formation with SD-N:MD [1:6] compared to the nystatin reference suspension. The elaboration process and physicochemical properties of SD-N:MD [1:6] could be a promising strategy for treatment of Candida biofilms.engAtribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/Development of a Solid Dispersion of Nystatin with Maltodextrin as a Carrier Agent: Improvements in Antifungal Efficacy against Candida spp. Biofilm Infectionsjournal articlehttps://www.mdpi.com/journal/pharmaceuticalsopen access615.4615.282Solid dispersionNystatinAmorphous formMaltodextrinBiofilmsCandida albicansTecnología farmaceútica