Río Cantero, Natalia delMourelle Martínez, RosaSagastizabal Cardelús, BelénNova García, Manuel Joaquín De2024-03-132024-03-132024-03-06Río Cantero N del, Mourelle Martínez M.R., Sagastizabal Cardelús B., Nova García J M de. Influence of zoledronic acid and pamidronate on tooth eruption in children with osteogenesis imperfecta, Bone, 2023 Mar 6; 1170698756-3282https://doi.org/10.1016/j.bone.2024.117069https://hdl.handle.net/20.500.14352/102192Introduction Osteogenesis imperfecta (OI) is a congenital disease comprising a heterogeneous group of inherited connective tissue disorders. The main treatment in children is bisphosphonate therapy. Previous animal studies have shown that bisphosphonates delay tooth eruption. The aim of this study is to determine whether patients with OI treated with pamidronate and/or zoledronic acid have a delayed eruption age compared to a control group of healthy children. Methods An ambispective longitudinal cohort study evaluating the age of eruption of the first stage mixed dentition in a group of children with OI (n = 37) all treated with intravenous bisphosphonates compared with a group of healthy children (n = 89). Within the study group, the correlation (Pearson correlation test) between the type of medication administered (pamidronate and/or zoledronic acid) and the chronology of tooth eruption is established, as well as the relationship between the amount of cumulative dose received and tooth eruption. Results The age of eruption of the study group was significantly delayed compared to the age of eruption of the control group for molars and lateral incisors (p < 0.05). Patients who received higher cumulative doses had a delayed eruption age compared to those with lower cumulative doses (p < 0.05). There is a high positive correlation between age of delayed tooth eruption and Zoledronic acid administration. Conclusion Patients with OI have a delayed eruption of the 1st stage mixed dentition compared to a control group of healthy children. This delayed eruption is directly related to the cumulative dose of bisphosphonates and the administration of zoledronic ac.engAttribution-ShareAlike 4.0 Internationaljournal article1873-2763https://www.sciencedirect.com/science/article/pii/S8756328224000589?via%3Dihubopen access616.314-053.2616.71Osteogenesis imperfectaBisphosphonatesDental eruptionZoledronic acidPamidronateCiencias BiomédicasOdontología (Odontología)Odontología infantilFarmacología (Medicina)32 Ciencias Médicas3213.13 Ortodoncia-Estomatología3207.14 Osteopatología