Cabellos. MercedesLabalde Martínez, MaríaTorralba, MiguelRodríguez Fraile, José RamónAtance Martínez, Juan Carlos2024-02-052024-02-052018-03-15Cabellos Olivares M, Labalde Martínez M, Torralba M, Rodríguez Fraile JR, Atance Martínez JC. C-reactive protein as a marker of the surgical stress reduction within an ERAS protocol (Enhanced Recovery After Surgery) in colorectal surgery: A prospective cohort study. J Surg Oncol. 2018;117:717–724. https://doi.org/10.1002/jso.249090022-479010.1002/jso.24909https://hdl.handle.net/20.500.14352/98964Background: The aim of this study is to evaluate the effectiveness of an Enhanced Recovery After Surgery Protocol (ERAS) in relation to reduce the Systemic Inflammatory Response (SIR) to surgery using C-reactive protein (CRP) in the first (POD1), second (POD2) and third (POD3) postoperative day. Methods: We enrolled 121 patients (ERAS group) that underwent elective colorectal surgery with ERAS, and compared them with 135 patients (preERAS group) that had undergone surgery prior to the implementation. We made a univariate analysis to compare the CRP values in POD1, POD2, and POD3 between preERAS/ERAS group, laparoscopic/open surgery and the presence or not of Clavien Dindo complications. Multivariable lineal regression was used to assess if the ERAS had a decreasing effect on the CRP in POD1, POD2, and POD3, and was adjusted by age, male sex, use of laparoscopy, and complications. Results: The presence of complications was independently associated with an increase in CRP values ​​in POD1, POD2, and POD3. Laparoscopy in POD1 and POD2, and ERAS in POD2 was independently associated with a decrease in CRP values. Conclusion: The analysis shows an increase in SIR measured as a CRP value in those patients that had complications. The SIR decreased with laparoscopy in POD1 and POD2 and with ERAS in POD2.engjournal articlehttps://onlinelibrary.wiley.com/doi/10.1002/jso.2490929355975https://pubmed.ncbi.nlm.nih.gov/29355975/restricted access617-089.5Proteina C reactivaRecuperacion intensificadaC-reactive proteinColorectal surgeryEnhanced recovery after surgery protocolSystemic inflammatory response.Ciencias Biomédicas32 Ciencias Médicas