Izquierdo, AnaCabello, MaríaLeal, ItziarMellor-Marsá, BlancaAyora, MiriamBravo Ortiz, María FeIbáñez, ÁngelaMac-Dowell Mata, Karina SoledadMalpica, NorbertoBaca García, EnriqueFares Otero, Natalia E.Melero, HelenaLópez García, PilarDíaz Caneja, Covadonga M.Ayuso Mateos, Jose LuisDurán Cutilla, ManuelMerchán Naranjo, JessicaMediavilla Torres, RobertoMuñoz Sanjosé, AinoaSanchez Pastor, LuisDompablo, MonicaFernández Martín, PatriciaPuras Rico, PabloAlbarracin García, LucíaMelero Carrasco, HelenaRodríguez Jiménez, RobertoDíaz Marsa, Marina FranciscaArango López, CelsoGarcía-Albea Martín, Julia IsabelLeza Cerro, Juan CarlosLeón Quismondo, Leticia2024-02-082024-02-082021-04Izquierdo A, Cabello M, Leal I, Mellor-Marsá B, Ayora M, Bravo-Ortiz M-F, et al. The interplay between functioning problems and symptoms in first episode of psychosis: An approach from network analysis. J Psychiatr Res [Internet]. 2021;136:265–73.0022-395610.1016/j.jpsychires.2021.02.024https://hdl.handle.net/20.500.14352/100254The relationship between psychotic symptoms and global measures of functioning has been widely studied. No previous study has assessed so far the interplay between specific clinical symptoms and particular areas of functioning in first-episode psychosis (FEP) using network analysis methods. A total of 191 patients with FEP (age 24.45 ± 6.28 years, 64.9% male) participating in an observational and longitudinal study (AGES-CM) comprised the study sample. Functioning problems were assessed with the WHO Disability Assessment Schedule (WHODAS), whereas the Positive and Negative Syndrome Scale (PANSS) was used to assess symptom severity. Network analysis were conducted with the aim of analysing the patterns of relationships between the different dimensions of functioning and PANSS symptoms and factors at baseline. According to our results, the most important nodes were “conceptual disorganization”, “emotional withdrawal”, “lack of spontaneity and flow of conversation”, “delusions”, “unusual thought content”, “dealing with strangers” and “poor rapport”. Our findings suggest that these symptoms and functioning dimensions should be prioritized in the clinical assessment and management of patients with FEP. These areas may also become targets of future early intervention strategies, so as to improve quality of life in this population.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/journal article0022-3956https//doi.org/10.1016/j.jpsychires.2021.02.024https://www.sciencedirect.com/science/article/pii/S0022395621000911?via%3Dihubopen access616.89-02616.89First episode of psychosisFunctioningNetwork analysisNeuropsicología3211 Psiquiatría