Twenty-first century antiepileptic drugs. An overview of their targets and synthetic approaches

Sánchez Cebrián, Juan DomingoGonzález Matilla, Juan FranciscoMenéndez Ramos, José Carlos2024-05-222024-05-222024-05-040223-523410.1016/j.ejmech.2024.116476https://hdl.handle.net/20.500.14352/104302The therapeutic use of the traditional drugs against epilepsy has been hindered by their toxicity and low selectivity. These limitations have stimulated the design and development of new generations of antiepileptic drugs. This review explores the molecular targets and synthesis of the antiepileptic drugs that have entered the market in the 21st century, with a focus on manufacturer synthesis.engAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Twenty-first century antiepileptic drugs. An overview of their targets and synthetic approachesjournal articlehttps://www.sciencedirect.com/science/article/pii/S0223523424003568?via%3Dihubopen access615:54615.31Antiepileptic targetsDrug synthesisHeterocyclesPeptidomimeticsNeurosteroidsQuímica farmaceútica32 Ciencias Médicas