New procedures for the synthesis of heterocyclic substituted and 2,4-difunctionalized pyrimidines

García Martínez, AntonioHerrera Fernández, AntonioMoreno Jiménez, FlorencioMuñoz Martínez, Pablo J.Alonso Martín, CristinaSubramanian, Laksminarayanapuran R.2023-06-202023-06-201996-06-030040-402010.1016/0040-4020(96)00368-7https://hdl.handle.net/20.500.14352/58170Received in UK 15 March 1996; revised 2 April 1996; accepted 12 April 1996N-Tosyl-2- and -3-acetylpyrrols 1 or N-tosyl-2-pyrrolidone 5 were condensed with cyano compounds in the presence of triflic anhydride (Tf2O) to yield heteroarylpyrimidines. 2,4 Difunctionalized pyrimidines were obtained by reaction of the corresponding 2,4-bis(methylsulfonyl)pyrimidines with nucleophiles.engNew procedures for the synthesis of heterocyclic substituted and 2,4-difunctionalized pyrimidinesjournal articlehttps://doi.org/10.1016/0040-4020(96)00368-7restricted access542.966.091Heterocyclic synthesisheteroarylpyrimidines.Química orgánica (Química)2306 Química Orgánica