Ríos Dueñas, EstherMedrano, SaraÁlvarez, MarValderrama Conde, María JoséVallejo, LuisDelgado-Iribarren García-Campero, AlbertCulebras López, Esther2025-09-032025-09-032022-12-17Ríos, E., Medrano, S., Alvarez, M., Valderrama, M. J., Vallejo, L., Delgado-Iribarren, A., & Culebras, E. (2023). High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load. International Microbiology, 26(3), 471-474. https://doi.org/10.1007/S10123-022-00311-31139-670910.1007/s10123-022-00311-3https://hdl.handle.net/20.500.14352/123653This study was supported by the Community of Madrid and the European Union, through the European Regional Development Fund (ERDF), supported as part of the Union’s response to the COVID-19 pandemic (PROYECTO REACT-EU INMUNOVACTER-CM).ADVIA Centaur SARS-CoV-2 Antigen (COV2Ag) Assay (Siemens Healthineers) was evaluated for SARS-CoV-2 detection. A total of 141 nasopharyngeal samples were analyzed by this technique and results were compared with those obtained by quantitative reverse-transcription polymerase chain reaction (RT-PCR). The overall sensitivity and specificity of the test were 68.70% and 70%, respectively. Regarding cycle threshold (Ct) values, the COV2Ag test showed a sensitivity of 93.75% and 100% for nasopharyngeal samples with Ct < 25 and < 20, respectively. ADVIA Centaur COV2Ag Assay is a useful, automated, and rapid technique for early SARS-CoV-2 diagnosis and isolation of the infected individuals, avoiding its transmission.engAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/journal article1618-1905https://doi.org/10.1007/s10123-022-00311-3https://link.springer.com/article/10.1007/s10123-022-00311-3open access579578.7578.834579.61616.98SARS-CoV-2Rapid antigen testPCRSensitivitySpecifcityMicrobiología (Biología)Microbiología médicaEnfermedades infecciosas2414 Microbiología2420 Virología2420.08 Virus Respiratorios3205.05 Enfermedades Infecciosas